Misdiagnosing renal amyloidosis as minimal change disease
نویسندگان
چکیده
منابع مشابه
Misdiagnosing renal amyloidosis as minimal change disease.
BACKGROUND Minimal change disease (MCD) accounts for 10-15% of all adult nephrotic syndrome cases and requires normal renal histology by light microscopy and negative immunohistology. Foot process effacement on electron microscopy (EM) is typical. Renal amyloid deposits demonstrate pathognomonic green birefringence when viewed under cross-polarized light after staining tissue with Congo red (CR...
متن کاملMinimal Change Disease.
Minimal change disease (MCD) is a major cause of idiopathic nephrotic syndrome (NS), characterized by intense proteinuria leading to edema and intravascular volume depletion. In adults, it accounts for approximately 15% of patients with idiopathic NS, reaching a much higher percentage at younger ages, up to 70%-90% in children >1 year of age. In the pediatric setting, a renal biopsy is usually ...
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Nephrotic syndrome is a common illness dating back to the 15th century and known to affect both children and adults [1]. There are three distinct histological variants of primary idiopathic nephrotic syndrome, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS) and membranous nephropathy (MN), which is rare in children. In clinical practice, ∼95% MCD patients respond to cort...
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Minimal change disease (MCD) is a histopathological lesion in the kidney that is most commonly associated with nephrotic syndrome. The majority of the cases are idiopathic. Pathogenesis is not well understood, although T-cell-related mechanisms are implicated. Massive proteinuria leads to hypoalbuminemia, salt retention, disorder of hemostasis, hyperlipidemia and increased susceptibility to inf...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2014
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfu242